Solute and water transport along an inner medullary collecting duct undergoing peristaltic contractions
نویسندگان
چکیده
منابع مشابه
CaR Regulates Water Permeability of Rat Inner Medullary Collecting Duct
During antidiuresis, increases in vasopressin (AVP)-elicited osmotic water permeability in the terminal inner medullary collecting duct (tIMCD) raise luminal calcium concentrations to levels ( $ 5 mM) above those associated with the formation of calcium-containing precipitates in the urine. Calcium/polycation receptor proteins (CaRs) enable cells in the parathyroid gland and kidney thick ascend...
متن کاملWater transport in cultured cells from the rat inner medullary collecting duct.
In this study, cells derived from rat inner medullary collecting duct formed a polarized monolayer when grown in wells on a membrane. When the membrane was sealed in an Ussing apparatus, the cells passed water from their apical to basolateral surfaces in the presence of an osmotic gradient. This was detected by the movement of the meniscus (1 mm = 1 microL) in a capillary tube connected to the ...
متن کاملPhosphoinositide signaling in rat inner medullary collecting duct.
Previous studies in microdissected rat inner medullary collecting duct (IMCD) segments have demonstrated that carbachol, arginine vasopressin (AVP), and the V2 vasopressin receptor agonist 1-desamino-8-d-arginine vasopressin (DDAVP) induce a similar increase in intracellular Ca2+. The present study tested whether these agents activate the phosphoinositide hydrolysis pathway. In intracellular in...
متن کاملEndothelin production by human inner medullary collecting duct cells.
T he inner medubbary collecting duct (IMCD) is the major nephron site of endothelin1 (ET1 ) production ( 1 ) in experimental animals. Subsequent studies have determined that ET1 binds to highdensity. high-affinity receptors on IMCD cells (2). resulting in potent inhibition of water transport (3) and Na/K ATPase activity (4). Hence, this peptide may function as an autocnine regulator of IMCD sod...
متن کاملSyntaxin specificity of aquaporins in the inner medullary collecting duct.
Proper targeting of the aquaporin-2 (AQP2) water channel to the collecting duct apical plasma membrane is critical for the urine concentrating mechanism and body water homeostasis. However, the trafficking mechanisms that recruit AQP2 to the plasma membrane are still unclear. Snapin is emerging as an important mediator in the initial interaction of trafficked proteins with target soluble N-ethy...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2019
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00265.2019